Is High-Sensitivity Troponin Actually Helping Us?

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This RCT of U.S. patients being evaluated for acute MI using a 0/1 hour hs-cTnI protocol, compared to standard care with a 0/3 hour hs-cTnI protocol, didn’t find a difference in the percentage of patients discharged from the ED nor in the rates of 30 day death or MI.

The authors found the accelerated protocol (57.8% discharged) was not superior to standard care (59.5%) with regard to the proportion of patients discharged. The accelerated protocol and standard care groups both had rates of death or MI at 30 days of 0.4%.

Source

Rapid Acute Coronary Syndrome Evaluation Over One Hour With High-Sensitivity Cardiac Troponin I: A United States-Based Stepped-Wedge, Randomized Trial. Ann Emerg Med. 2024 Jun 15:S0196-0644(24)00235-X. doi: 10.1016/j.annemergmed.2024.04.024. Epub ahead of print. PMID: 38888531.